In search of the neuroprotective mechanism of thiazolidinediones in Parkinson's disease

Exp Neurol. 2012 Dec;238(2):133-7. doi: 10.1016/j.expneurol.2012.08.012. Epub 2012 Aug 19.


The oral antidiabetic thiazolidinediones exert protective effects in models of Parkinson's disease and other neurological diseases. While the antidiabetic effect is due to activation of PPARγ, the mechanisms underlying the neuroprotection are more controversial. It may involve activation of PPARγ blocking inflammation and apoptosis. However, new evidence suggests an antioxidative PPARγ-independent action. Here we discuss recent data on the mode of action of TZDs in models of PD and their implication for the translation into the clinic.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antioxidants / therapeutic use*
  • Disease Models, Animal*
  • Humans
  • Male
  • PPAR gamma / agonists*
  • PPAR gamma / antagonists & inhibitors*
  • Parkinson Disease / prevention & control*


  • Antioxidants
  • PPAR gamma