Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice

Gastroenterology. 2013 Feb;144(2):294-7. doi: 10.1053/j.gastro.2012.10.030. Epub 2012 Oct 22.

Abstract

Imaging strategies that detect early stage esophageal squamous cell carcinoma (ESCC) could improve clinical outcomes, when combined with endoscopic approaches. Periostin is an integrin-binding protein that is important in the tumor microenvironment. We created a fluorescent-labeled antibody that recognizes periostin and binds specifically to ESCC xenograft tumors in mice. In L2-cre;p120ctnLoxP/LoxP mice, which develop squamous cell cancers that resemble human ESCC, we visualized the probe in preneoplastic and neoplastic esophageal lesions using near-infrared fluorescent imaging with upper-gastrointestinal endoscopy. Periostin might be a biomarker of the esophageal tumor microenvironment that can be used to detect preneoplastic lesions.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / diagnosis*
  • Diagnosis, Differential
  • Early Diagnosis*
  • Esophageal Neoplasms / diagnosis*
  • Esophagoscopy / methods*
  • Humans
  • Mice
  • Neoplasms, Experimental*
  • Optical Imaging / methods*