Effect of dietary zinc deficiency on ischemic vulnerability of the brain

Neurosci Lett. 2012 Nov 30;531(1):10-3. doi: 10.1016/j.neulet.2012.10.013. Epub 2012 Oct 17.


Deficiency of zinc, which modulates glutamate release, might increase ischemic vulnerability of the brain. We examined effects of dietary zinc deficiency for 2 weeks on ischemic vulnerability in several brain regions using dynamic positron autoradiography technique and [18F]2-fluoro-2-deoxy-d-glucose with rat brain slices. In the normal diet group, the cerebral glucose metabolic rate (CMRglc) was not significantly different from that of the ischemia-unloaded control even after the loading of ischemia for 45 min. However, in the zinc-deficient diet group, CMRglc was significantly lower than that of the ischemia-unloaded control after loading of ischemia for 45 min. With treatment of MK-801 (NMDA receptor antagonist) from the start of ischemia loading, CMRglc was not significantly different from that of the ischemia-unloaded control. These findings, obtained for all analyzed brain regions, suggest that dietary zinc deficiency increased ischemic vulnerability in the brain, and that glutamate might contribute to this effect through activation of the NMDA receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoradiography / methods
  • Brain Ischemia / blood
  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / drug therapy
  • Brain Ischemia / etiology
  • Brain Ischemia / metabolism*
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism*
  • Diet
  • Disease Models, Animal
  • Dizocilpine Maleate / pharmacology
  • Dizocilpine Maleate / therapeutic use
  • Excitatory Amino Acid Antagonists / pharmacology
  • Excitatory Amino Acid Antagonists / therapeutic use
  • Fluorodeoxyglucose F18
  • Glucose / metabolism*
  • Radionuclide Imaging
  • Rats
  • Rats, Wistar
  • Zinc / deficiency*
  • Zinc / metabolism


  • Excitatory Amino Acid Antagonists
  • Fluorodeoxyglucose F18
  • Dizocilpine Maleate
  • Glucose
  • Zinc