Prediction of transporter-mediated drug-drug interactions using endogenous compounds

Clin Pharmacol Ther. 2012 Nov;92(5):546-8. doi: 10.1038/clpt.2012.145.


Therapy with two or more drugs is more the rule than the exception, particularly in aging societies. Drug-drug interactions are frequently undesirable and may lead to increased toxicity and mortality. Inhibition of transporters is one major mechanism underlying drug-drug interactions. The myriad of potential drug combinations makes it very challenging to predict drug-drug interactions. This Commentary discusses potential advantages and limitations of endogenous compounds for predicting transporter-mediated drug-drug interactions.

Publication types

  • Comment

MeSH terms

  • Humans
  • Kidney / metabolism*
  • Male
  • Niacinamide / analogs & derivatives*
  • Niacinamide / metabolism
  • Organic Cation Transport Proteins / metabolism*


  • Organic Cation Transport Proteins
  • SLC47A1 protein, human
  • SLC47A2 protein, human
  • Niacinamide
  • N-methylnicotinamide