Recent investigations have shown excess postexercise oxygen consumption (EPOC) to be elevated for up to 48 hours in both untrained and trained subjects after resistance training (RT). The purpose of this study was to investigate the effect of load-volume on EPOC. Eight trained men (aged 22 ± 3 years) participated in 2 randomized RT bouts separated by at least 1 week with total load-volumes of 10,000 and 20,000 kg, respectively. Intensity of RT (85% 1 repetition maximum) did not differ between trials. Exercise energy expenditure and resting metabolic rate (RMR) were measured by indirect calorimetry at 8.5 hours before, 1.5 hours before, and during RT bouts and 12, 24, 36, and 48 hours after exercise. Creatine kinase (CK) was measured before and after RT, and 12, 24, 36, and 48 hours postexercise; ratings of perceived muscle soreness were measured on a similar time course save the immediate postexercise time point. Analysis of variance with repeated measures was used to analyze dependent variables. During the 20,000 kg trial, subjects expended significantly (p < 0.01) more energy (484 ± 29 kcal) than the 10,000 kg lift (247 ± 18 kcal). After the 20,000 kg lift, 12 hours postexercise, CK (1,159 ± 729 U·L) was significantly elevated (p < 0.05) as compared with baseline (272 ± 280 U·L) and immediately postexercise (490 ± 402 U·L). No significant time or trial differences were found in RMR between the 10,000 and 20,000 kg trials. In conclusion, high-intensity RT with load-volumes of up to 20,000 kg using resistance-trained men does not significantly increase EPOC above baseline RMR.