Complete genome sequence of a novel porcine circovirus type 2b variant present in cases of vaccine failures in the United States

J Virol. 2012 Nov;86(22):12469. doi: 10.1128/JVI.02345-12.

Abstract

Two genomes of a new porcine circovirus type 2 (PCV2) strain associated with cases of perceived failure of PCV2 vaccination were sequenced and analyzed. Based on the genome, this is the first report of this mutant of PCV2b in the United States. The genomic knowledge of this mutant PCV2b will improve understanding of the epidemiology of PCV and potentially inform the development of new and more effective vaccines for PCV2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Circovirus / genetics*
  • DNA, Viral / genetics
  • Databases, Genetic
  • Genes, Viral
  • Genome, Viral*
  • Genomics
  • Molecular Sequence Data
  • Mutation
  • Open Reading Frames
  • Phylogeny
  • Sequence Analysis, DNA
  • United States
  • Viral Vaccines / immunology*

Substances

  • DNA, Viral
  • Viral Vaccines

Associated data

  • GENBANK/JX535296
  • GENBANK/JX535297