Experimental Evaluation of Analgesic and Anti-Inflammatory Activity of Simvastatin and Atorvastatin

Indian J Pharmacol. Jul-Aug 2012;44(4):475-9. doi: 10.4103/0253-7613.99311.

Abstract

Aim: The aim of this study is to evaluate the analgesic and anti-inflammatory activities of atorvastatin and simvastatin in different experimental models in mice and rats.

Materials and methods: Analgesic activity of simvastatin and atorvastatin was assessed in tail flick model in rats (n = 6), where it was compared with aspirin and tramadol and in acetic acid induced writhing in mice (n = 6), where it was compared with aspirin. Anti-inflammatory activity of statins was evaluated using carrageenin induced paw edema and formalin induced arthritis in rats.

Results: In the tail flick method, analgesic effect of tramadol was significantly more than the other drugs except at two observation times, when it was comparable to simvastatin and atorvastatin. Effect of simvastatin was found to be comparable to aspirin. In acetic acid induced writhing method, analgesic activity of simvastatin was comparable to that of aspirin while that of atorvastatin was significantly less. In carrageenin induced paw edema in rats, both simvastatin and atorvastatin showed anti-inflammatory activity which was comparable to aspirin. Both the statins exhibited significant anti-inflammatory activity (P < 0.01) in formalin induced arthritis model though less than aspirin (P < 0.05).

Conclusion: The results of this study if substantiated by further experimental and clinical research suggest that simvastatin and atorvastatin may play an adjuvant role, which may be particularly beneficial in the treatment of inflammatory disorders, especially when there is coexisting dyslipidemia.

Keywords: Formalin induced arthritis; paw edema; statins; tail-flick method; writhing.

MeSH terms

  • Analgesics / pharmacology
  • Analgesics / therapeutic use*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Atorvastatin
  • Drug Evaluation, Preclinical / methods
  • Edema / drug therapy
  • Edema / pathology
  • Female
  • Heptanoic Acids / pharmacology
  • Heptanoic Acids / therapeutic use*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Male
  • Mice
  • Pain / drug therapy*
  • Pain / pathology
  • Pain Measurement / drug effects*
  • Pain Measurement / methods
  • Pyrroles / pharmacology
  • Pyrroles / therapeutic use*
  • Rats
  • Rats, Wistar
  • Simvastatin / pharmacology
  • Simvastatin / therapeutic use*

Substances

  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Heptanoic Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrroles
  • Atorvastatin
  • Simvastatin