The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation

Genome Biol. 2012 Oct 22;13(10):251. doi: 10.1186/gb-2012-13-10-251.

Abstract

Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cellular Reprogramming
  • Epigenesis, Genetic
  • Genome
  • Humans
  • Kruppel-Like Transcription Factors / metabolism*
  • Octamer Transcription Factor-3 / metabolism*
  • Pluripotent Stem Cells / metabolism*
  • SOXB1 Transcription Factors / metabolism*

Substances

  • GKLF protein
  • Kruppel-Like Transcription Factors
  • Octamer Transcription Factor-3
  • SOXB1 Transcription Factors