Uric acid stones and hyperuricosuria

Adv Chronic Kidney Dis. 2012 Nov;19(6):413-8. doi: 10.1053/j.ackd.2012.07.014.


Recent work has highlighted the strong relationships among obesity, diabetes, and the metabolic syndrome as causes of low urinary pH. Low urinary pH in turn is the major urinary risk factor for uric acid stones. Unlike calcium stones, uric acid stones can be dissolved and easily prevented with adequate urinary alkalinization. Recognizing the relevant risk factors should lead to increased identification of these radiolucent stones. The cornerstone of therapy is raising urinary pH; xanthine dehydrogenase inhibitors should be used only when urinary alkalinization cannot be achieved.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Enzyme Inhibitors / therapeutic use
  • Gout / urine*
  • Humans
  • Hydrogen-Ion Concentration
  • Risk Factors
  • Uric Acid / urine*
  • Urolithiasis / metabolism*
  • Urolithiasis / prevention & control
  • Xanthine Dehydrogenase / antagonists & inhibitors


  • Enzyme Inhibitors
  • Uric Acid
  • Xanthine Dehydrogenase