Mercury-thymine interaction with a chair type G-quadruplex architecture

Chem Commun (Camb). 2012 Dec 4;48(93):11464-6. doi: 10.1039/c2cc36481f. Epub 2012 Oct 23.

Abstract

The T-Hg-T bond was utilized to cross-link two lateral loops of chair-type G-quadruplex DNA (G4-DNA) structures. Two out of five cross-linking geometries are able to increase the melting temperature and simultaneously reduce the polymorphism of the G4-DNA conformations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA / chemistry
  • DNA / genetics
  • G-Quadruplexes* / drug effects
  • Mercury / chemistry*
  • Mercury / pharmacology
  • Models, Molecular
  • Thymine / chemistry*

Substances

  • DNA
  • Mercury
  • Thymine