HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene

Science. 1990 Mar 2;247(4946):1082-4. doi: 10.1126/science.2309119.


Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human beta-polymerase (hu beta-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cell Line
  • Cell Line, Transformed
  • DNA Polymerase I / genetics*
  • DNA, Viral / genetics
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Viral
  • Human T-lymphotropic virus 1 / genetics*
  • Humans
  • Molecular Sequence Data
  • Plasmids
  • Promoter Regions, Genetic
  • RNA, Messenger / biosynthesis
  • Repetitive Sequences, Nucleic Acid
  • Repressor Proteins / biosynthesis
  • Repressor Proteins / genetics*
  • Trans-Activators / biosynthesis
  • Trans-Activators / genetics*
  • Transcription Factors / genetics*
  • Transfection


  • DNA, Viral
  • RNA, Messenger
  • Repressor Proteins
  • Trans-Activators
  • Transcription Factors
  • DNA Polymerase I