The potential benefit of stem cell therapy after stroke: an update

Vasc Health Risk Manag. 2012;8:569-80. doi: 10.2147/VHRM.S25745. Epub 2012 Oct 10.


Stroke is a leading cause of death and disability worldwide. Stem cell therapy is an emerging therapeutic modality with evidence of significant benefits in preclinical stroke models. A number of phase I and II clinical trials have now been completed, with several more currently under way. Translation to the bedside, however, remains a long way off, and there are many questions that remain unanswered. This review will summarize the current evidence and ongoing clinical trials worldwide, and explore the challenges to making this a realistic treatment option for the future.

Keywords: clinical trials; stem cells; stroke.

Publication types

  • Review

MeSH terms

  • Cell Line
  • Clinical Trials as Topic
  • Hematopoietic Stem Cell Mobilization
  • Humans
  • Mesenchymal Stem Cells / physiology
  • Neovascularization, Physiologic / physiology
  • Neural Stem Cells / physiology
  • Neurogenesis / physiology
  • Stem Cell Transplantation* / methods
  • Stem Cell Transplantation* / trends
  • Stroke / therapy*
  • Translational Research, Biomedical*
  • Treatment Outcome