Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 18 (3), 309-15

Type and Cause of Liver Disease in Korea: Single-Center Experience, 2005-2010

Affiliations

Type and Cause of Liver Disease in Korea: Single-Center Experience, 2005-2010

Sang Soo Lee et al. Clin Mol Hepatol.

Abstract

Background/aims: The aim of this study was to describe the types and causes of liver disease in patients from a single community hospital in Korea between April 2005 and May 2010.

Methods: A cohort of patients who visited the liver clinic of the hospital during the aforementioned time period were consecutively enrolled (n=6,307). Consistent diagnostic criteria for each liver disease were set by a single, experienced hepatologist, and the diagnosis of all of the enrolled patients was confirmed by retrospective review of their medical records.

Results: Among the 6,307 patients, 528 (8.4%) were classified as acute hepatitis, 3,957 (62.7%) as chronic hepatitis, 767 (12.2%) as liver cirrhosis, 509 (8.1%) as primary liver cancer, and 546 (8.7%) as a benign liver mass or other diseases. The etiologies in the acute hepatitis group in decreasing order of prevalence were hepatitis A (44.3%), toxic hepatitis (32.4%), other hepatitis viruses (13.8%), and cryptogenic hepatitis (9.1%). In the chronic hepatitis group, 51.2% of cases were attributed to viral hepatitis, 33.3% to nonalcoholic fatty liver disease, and 13.0% to alcoholic liver disease (ALD). Of the cirrhoses, 73.4% were attributable to viral causes and 18.1% to alcohol. Of the hepatocellular carcinoma cases, 86.6% were attributed to viral hepatitis and 11.6% to ALD. Among the benign tumors, hemangioma comprised 52.2% and cystic liver disease comprised 33.7%.

Conclusions: Knowledge of the current status of the type and cause of liver disease in Korea may be valuable as a basis for evaluating changing trends in liver disease in that country.

Keywords: Diagnosis; Etiology, Korea; Liver disease.

Conflict of interest statement

The authors have no conflicts to disclose.

Figures

Figure 1
Figure 1
The prevalence of liver disease types. Chronic hepatitis was the most common type of liver disease in this cohort, comprising 62.7% of the liver diseases, followed by liver cirrhosis (12.2%), acute hepatitis (8.4%), primary liver cancer (8.1%), other benign disease (8.1%), and metastatic liver cancer (0.6%).
Figure 2
Figure 2
Overall causes of chronic liver disease. The viral cause of chronic liver disease progressively increased from chronic hepatitis to cirrhosis, and finally to hepatocellular carcinoma (HCC; 51.2%, 73.4%, and 86.6%, respectively), while that of nonalcoholic fatty liver disease (NAFLD) progressively decreased in the same order (33.3%, 6.6%, and 1.8%, respectively). HCC, hepatocellular carcinoma; NAFLD, nonalcoholic fatty liver disease.
Figure 3
Figure 3
The cause of acute hepatitis. The main etiologies of acute hepatitis were hepatitis A virus (HAV; 44.3%), toxic hepatitis (32.4%), and HCV (6.4%); HAV and hepatitis C virus (HCV) were observed together in two patients, and HAV and hepatitis E virus (HEV) were observed together in six. HAV, hepatitis A virus; HBV, hepatitis B virus; EBV, Epstein-Barr virus.
Figure 4
Figure 4
Classification of chronic liver disease according to viral etiology. Among the causes of chronic viral hepatitis, HBV/HCV was the cause in 82.0%/17.5%, while in cirrhosis and HCC, HBV/HCV was the cause in 83.7%/15.5% and 74.9%/24.1% of cases, respectively. HCC, hepatocellular carcinoma; HBV, hepatitis B virus; HCV, hepatitis C virus.

Similar articles

See all similar articles

Cited by 16 PubMed Central articles

See all "Cited by" articles

References

    1. Kochanek KD, Xu J, Murphy SL, Miniño AM, Kung HC. National vital statistics report. Deaths: Preliminary Data for 2009. Vol. 59. Centers for Disease Control and Prevention; 2011. pp. 1–51. - PubMed
    1. Korea National Statical Office. Annual Report on the Cause of Death Statics 2010. 2011.
    1. Lee S, Chung W, Hyun KR. Socioeconomic costs of liver disease in Korea. Korean J Hepatol. 2011;17:274–291. - PMC - PubMed
    1. Korean Liver Cancer Study Group and National Cancer Center, Korea. Practice guidelines for management of hepatocellular carcinoma 2009. Korean J Hepatol. 2009;15:391–423. - PubMed
    1. Kang HM, Jeong SH, Kim JW, Lee D, Choi CK, Park YS, et al. Recent etiology and clinical features of acute viral hepatitis in a single center of Korea. Korean J Hepatol. 2007;13:495–502. - PubMed

MeSH terms

Feedback