Labeled vs actual concentration of bleaching agents

Oper Dent. 2013 May-Jun;38(3):334-43. doi: 10.2341/11-367-L. Epub 2012 Oct 23.

Abstract

The purpose of this study was to determine if the actual concentration of bleaching agents available in four different countries were the same as the label indicated and within the recommendations of the International Standard on Tooth Whitening. The method recommended for assaying peroxide by the United States Pharmacopeia was used to determine concentrations. All products in the United States and China were within the standard when products were tested immediately upon delivery at testing sites. One product in Saudi Arabia and three products in Brazil had greater than 30% concentration loss. Three of 24 products in the United States did not meet the International Standard when they were tested at month of expiration.

MeSH terms

  • Brazil
  • Carbamide Peroxide
  • China
  • Drug Labeling / standards*
  • Drug Storage
  • Humans
  • Hydrogen Peroxide / administration & dosage
  • Hydrogen Peroxide / analysis
  • Hydrogen Peroxide / standards
  • Materials Testing
  • Peroxides / administration & dosage
  • Peroxides / analysis*
  • Peroxides / standards
  • Pharmacopoeias as Topic
  • Reference Standards
  • Saudi Arabia
  • Time Factors
  • Tooth Bleaching Agents / administration & dosage
  • Tooth Bleaching Agents / analysis*
  • Tooth Bleaching Agents / standards
  • United States
  • Urea / administration & dosage
  • Urea / analogs & derivatives
  • Urea / analysis
  • Urea / standards

Substances

  • Peroxides
  • Tooth Bleaching Agents
  • Carbamide Peroxide
  • Urea
  • Hydrogen Peroxide