The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases

Thromb Haemost. 2012 Dec;108(6):1089-96. doi: 10.1160/TH12-06-0396. Epub 2012 Oct 23.

Abstract

Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidity and mortality. Remarkable effort has been made to identify new drug targets. There is growing evidence indicating that the recently described counter-regulator axis of the renin-angiotensin system (RAS), composed of Angiotensin-Converting Enzyme 2 (ACE2), Angiotensin-(1-7) and the Mas receptor, has protective effects against thrombosis. In addition, it could be considered as a promising target for treating or preventing this disease. In this narrative review, we focused on the recent findings of the role of the ACE2/Angiotensin-(1-7)/Mas axis on the haemostatic process and its therapeutic potential.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiotensin II Type 1 Receptor Blockers / pharmacology
  • Angiotensin-Converting Enzyme 2
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology
  • Hemostasis / drug effects
  • Hemostasis / physiology
  • Humans
  • Models, Cardiovascular
  • Peptidyl-Dipeptidase A / physiology*
  • Proto-Oncogene Proteins / physiology*
  • Receptor, Angiotensin, Type 1 / physiology
  • Receptors, G-Protein-Coupled / physiology*
  • Renin-Angiotensin System / drug effects
  • Renin-Angiotensin System / physiology
  • Thrombosis / blood
  • Thrombosis / drug therapy*
  • Thrombosis / physiopathology*

Substances

  • Angiotensin II Type 1 Receptor Blockers
  • Angiotensin-Converting Enzyme Inhibitors
  • Proto-Oncogene Proteins
  • Receptor, Angiotensin, Type 1
  • Receptors, G-Protein-Coupled
  • proto-oncogene proteins c-mas-1
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2