Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983

Virology. 1990 Mar;175(1):59-68. doi: 10.1016/0042-6822(90)90186-u.


During 1988-1989 two highly distinct antigenic variants of influenza type B were recognized in hemagglutination-inhibition tests with postinfection ferret serum. These viruses were antigenically related to either B/Victoria/2/87, the most recent reference strain, or B/Yamagata/16/88, a variant that was isolated in Japan in May 1988. All influenza B viruses isolated in the United States during an epidemic in the winter of 1988-1989 were antigenically related to B/Victoria/2/87. However, in several countries in Asia, both B/Victoria/2/87-like viruses and B/Yamagata/16/88-like viruses were isolated. Sequence analysis of the hemagglutinin (HA) genes of several influenza B isolates from 1987 to 1988 indicated that the HA1 domains of the B/Yamagata/16/88-like viruses and B/VI/87-like viruses isolated in 1988 differed by 27 amino acids. Evolutionary relationships based on this sequence data indicated that the B/Yamagata/16/88-like viruses were more closely related to epidemic viruses from 1983 (B/USSR/100/83-like viruses) than to more recent reference strains such as B/Victoria/2/87. All other Asian strains, as well as selected isolates from the United States in 1988, were confirmed by sequence analysis as being genetically related to B/Victoria/2/87. These data provide clear evidence that two parallel evolutionary pathways of influenza type B have existed since at least 1983 and that viruses from each of the separate lineages were isolated from cases of influenza B in 1988. This finding is similar to earlier observations for type A H1N1 and H3N2 influenza viruses.

MeSH terms

  • Amino Acid Sequence
  • Antigens, Viral / genetics
  • Base Sequence
  • Biological Evolution*
  • Genes, Viral
  • Influenza B virus / genetics*
  • Influenza B virus / immunology
  • Influenza B virus / isolation & purification
  • Molecular Sequence Data
  • Oligonucleotide Probes


  • Antigens, Viral
  • Oligonucleotide Probes

Associated data

  • GENBANK/M58418
  • GENBANK/M58419
  • GENBANK/M58420
  • GENBANK/M58421
  • GENBANK/M58422
  • GENBANK/M58423
  • GENBANK/M58424
  • GENBANK/M58425
  • GENBANK/M58426
  • GENBANK/M58427