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. 2012 Nov 16;14(22):5804-7.
doi: 10.1021/ol302676v. Epub 2012 Oct 24.

Pd-catalyzed imine cyclization: synthesis of antimalarial natural products Aplidiopsamine A, Marinoquinoline A, and their potential hybrid NCLite-M1

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Pd-catalyzed imine cyclization: synthesis of antimalarial natural products Aplidiopsamine A, Marinoquinoline A, and their potential hybrid NCLite-M1

Jyoti P Mahajan et al. Org Lett. .

Abstract

Palladium-catalyzed cyclization of imines has been developed to construct the extremely rare 3H-pyrrolo[2,3-c]quinoline ring system for diversity oriented first total synthesis of antimalarial marine natural product Aplidiopsamine A as well as synthesis of Marinoquinoline A and potential natural product hybrid NCLite-M1.

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