Acute human immunodeficiency virus infection

Am J Med Sci. 2013 Feb;345(2):136-42. doi: 10.1097/MAJ.0b013e31825d4b88.


The clinical spectrum of acute human immunodeficiency virus (HIV) infection, a common clinical syndrome, may range from asymptomatic to a severe illness. The purpose of this review is to increase awareness of this syndrome, which is rarely suspected and often missed in clinical care settings, and provide an informative reference for primary care providers. The diagnosis of acute HIV infection is important for both patient care and public health concerns. In this article, the epidemiology, pathophysiology, clinical presentation, diagnosis and treatment of acute HIV infection are reviewed.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Anti-HIV Agents / therapeutic use
  • HIV Infections / diagnosis*
  • HIV Infections / epidemiology
  • HIV Infections / therapy*
  • HIV-1*
  • Humans
  • Randomized Controlled Trials as Topic / methods
  • Randomized Controlled Trials as Topic / trends


  • Anti-HIV Agents