Epigallocatechin-3-gallate Improves Acne in Humans by Modulating Intracellular Molecular Targets and Inhibiting P. Acnes

J Invest Dermatol. 2013 Feb;133(2):429-40. doi: 10.1038/jid.2012.292. Epub 2012 Oct 25.

Abstract

Acne vulgaris is a highly prevalent skin disorder characterized by hyperseborrhea, inflammation, and Propionibacterium acnes overgrowth. Only isotretinoin and hormonal therapy reduce sebum production. To identify a new drug candidate that modulates sebum, we examined the effects of EGCG, the major polyphenol in green tea, on human SEB-1 sebocytes and in patients with acne. In SEB-1 sebocytes, we found that EGCG reduced sebum by modulating the AMPK-SREBP-1 signaling pathway. EGCG also reduces inflammation by suppressing the NF-κB and AP-1 pathways. EGCG also induces cytotoxicity of SEB-1 sebocytes via apoptosis and decreases the viability of P. acnes, thus targeting almost all the pathogenic features of acne. Finally, and most importantly, EGCG significantly improved acne in an 8-week randomized, split-face, clinical trial, and was well tolerated. Our data provide a therapeutic rationale for the use of EGCG in acne.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinases / metabolism
  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / microbiology*
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Apoptosis / drug effects
  • Catechin / analogs & derivatives*
  • Catechin / pharmacology
  • Catechin / therapeutic use
  • Cell Line, Transformed
  • Child
  • Dermatitis / drug therapy
  • Dermatitis / microbiology
  • Double-Blind Method
  • Female
  • Gram-Positive Bacterial Infections / drug therapy*
  • Humans
  • Lipogenesis / drug effects
  • Male
  • NF-kappa B / metabolism
  • Propionibacterium acnes / drug effects*
  • Propionibacterium acnes / growth & development
  • Sebum / drug effects*
  • Sebum / microbiology
  • Signal Transduction / drug effects
  • Transcription Factor AP-1 / metabolism
  • Treatment Outcome

Substances

  • Antioxidants
  • NF-kappa B
  • Transcription Factor AP-1
  • Catechin
  • epigallocatechin gallate
  • AMP-Activated Protein Kinases