Transamidation of primary amides with amines catalyzed by zirconocene dichloride

Chem Commun (Camb). 2012 Dec 11;48(95):11626-8. doi: 10.1039/c2cc37427g.

Abstract

Zirconocene dichloride (Cp(2)ZrCl(2)) has been shown to be an effective catalyst for the transamidation of primary amides with amines in cyclohexane at 80 °C in 5-24 hours. For favourable substrates, the reaction can be performed at temperatures as low as 30 °C.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Amines / chemistry*
  • Carbamates / chemistry
  • Catalysis
  • Cyclohexanes / chemistry
  • Organometallic Compounds / chemistry*
  • Temperature
  • Zirconium / chemistry*

Substances

  • Amides
  • Amines
  • Carbamates
  • Cyclohexanes
  • Organometallic Compounds
  • Zirconocene dichloride
  • Cyclohexane
  • Zirconium