Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Mar;35(3):354-9.
doi: 10.1002/ajmg.1320350309.

Segregation Distortion in Inheritance of Progressive Rod Cone Degeneration (Prcd) in Miniature Poodle Dogs

Affiliations

Segregation Distortion in Inheritance of Progressive Rod Cone Degeneration (Prcd) in Miniature Poodle Dogs

G M Acland et al. Am J Med Genet. .

Abstract

Segregation distortion was observed in inheritance of progressive rod-cone degeneration (prcd) in a colony of Miniature Poodle dogs. Breeding results, from both retrospective records and prospectively planned matings, were classified into five mating types: (1) affected to affected, (2) homozygous normal sire to any dam, (3) heterozygous to heterozygous, (4) heterozygous sire to affected dam, and (5) affected sire to heterozygous dam. For all but the last category, results were in accord with mendelian expectations for autosomal-recessive inheritance. However, litters of mating type 5 had fewer affected pups (20/77) than expected. The observed segregation ratio for this mating type (0.26) was significantly (P less than 0.001) less than the expected (0.50). The segregation distortion could not be accounted for by either pre- or postnatal loss of affected pups, as litter size and litter survivability were uniform among litters of different mating types. Either the prcd locus, or a linked locus, would appear to influence either gametic or zygotic fitness in the heterozygous mother. Comparison is drawn to the inheritance of retinitis pigmentosa in humans, in which decreased segregation ratios are also recognized.

Similar articles

See all similar articles

Cited by 3 articles

Publication types

LinkOut - more resources

Feedback