Granzyme B in injury, inflammation, and repair

Trends Mol Med. 2012 Dec;18(12):732-41. doi: 10.1016/j.molmed.2012.09.009. Epub 2012 Oct 22.


Fragile skin and susceptibility to skin tearing are major problems among the elderly and can be complicated further by impaired wound healing. Non-healing wounds fail to progress through the normal stages of healing and enter a state of chronic inflammation featuring increased proteolytic activity. Increased expression of the serine protease granzyme B is observed during prolonged inflammation and is implicated in the pathogenesis of several chronic inflammatory diseases. Although its role in cytotoxic lymphocyte-mediated apoptosis is well established, granzyme B can also degrade extracellular matrix proteins and alter inflammation if present in the extracellular milieu. The present review focuses on the emerging evidence for the involvement of granzyme B in chronic inflammation, impaired wound healing, and age-related skin fragility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Extracellular Matrix Proteins / metabolism*
  • Granzymes / metabolism*
  • Humans
  • Inflammation / enzymology*
  • Models, Biological
  • Skin Aging / pathology*
  • Substrate Specificity
  • Wound Healing / physiology*


  • Extracellular Matrix Proteins
  • Granzymes