Cushing syndrome in pediatrics

Endocrinol Metab Clin North Am. 2012 Dec;41(4):793-803. doi: 10.1016/j.ecl.2012.08.002. Epub 2012 Sep 27.


Cushing syndrome is characterized by truncal obesity, growth deceleration, skin changes, muscle weakness, and hypertension. Cushing syndrome in childhood usually results from the exogenous administration of glucocorticoids. This article presents the causes and discusses the treatment of endogenous Cushing syndrome. It also discusses the clinical and molecular genetics of inherited forms of this syndrome. Cushing syndrome needs to be diagnosed and treated properly when first recognized; improper treatment can turn this otherwise completely curable disorder into a chronic ailment. Barriers to optimal care of a pediatric patient with Cushing syndrome are discussed.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Adenoma* / complications
  • Adenoma* / diagnosis
  • Adenoma* / therapy
  • Adrenal Gland Neoplasms* / complications
  • Adrenal Gland Neoplasms* / diagnosis
  • Adrenal Gland Neoplasms* / therapy
  • Child
  • Cushing Syndrome* / diagnosis
  • Cushing Syndrome* / etiology
  • Cushing Syndrome* / therapy
  • Glucocorticoids / adverse effects*
  • Humans
  • Pituitary ACTH Hypersecretion / complications
  • Pituitary ACTH Hypersecretion / diagnosis
  • Pituitary ACTH Hypersecretion / therapy
  • Pituitary Neoplasms* / complications
  • Pituitary Neoplasms* / diagnosis
  • Pituitary Neoplasms* / therapy


  • Glucocorticoids