Experimental and clinical findings from physical exercise as complementary therapy for epilepsy

Epilepsy Behav. 2013 Mar;26(3):273-8. doi: 10.1016/j.yebeh.2012.07.025. Epub 2012 Oct 23.


Complementary therapies for preventing or treating epilepsy have been extensively used. This review focuses on the positive effects of physical exercise programs observed in clinical studies and experimental models of epilepsy and their significance as a complementary therapy for epilepsy. Information about the antiepileptogenic and neuroprotective effects of exercise is highlighted. Considering that exercise can exert beneficial actions such as reduction of seizure susceptibility, reduction of anxiety and depression, and consequently, improvement of quality of life of individuals with epilepsy, exercise can be a potential candidate as non-pharmacological treatment of epilepsy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Complementary Therapies / methods*
  • Epilepsy / physiopathology
  • Epilepsy / rehabilitation*
  • Exercise / physiology*
  • Exercise Therapy / methods*
  • Humans