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Case Reports
. 1990 Mar;19(3):327-9.
doi: 10.1016/s0196-0644(05)82056-6.

Pathological Laughter

Case Reports

Pathological Laughter

G L Zellers et al. Ann Emerg Med. .


A man experienced one hour and 40 minutes of continual, inappropriate, uncontrollable laughter. The onset was preceded by a single-inhalation exposure to an insecticide of very low toxicity. The episode was terminated by a single dose of IV diazepam. A discussion of pathological laughter, including its proposed pathophysiology, differential diagnosis, clinical relevance, and management, is presented.

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