A missing link in genotype-directed cancer therapy

Cell. 2012 Oct 26;151(3):465-8. doi: 10.1016/j.cell.2012.10.014.


Genotype-directed therapy holds great promise for the treatment of cancer, but crosstalk between signaling pathways often confounds simple genotype-drug response relationships. To deliver on the promise of precision medicine, a coordinated effort is needed to make a comprehensive inventory of the many signaling feedback circuits that exist in cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / therapeutic use*
  • Drug Interactions
  • Feedback, Physiological
  • Genotype
  • Humans
  • Neoplasms / classification
  • Neoplasms / drug therapy*
  • Neoplasms / genetics*
  • Precision Medicine*
  • Signal Transduction*


  • Antineoplastic Agents