The role of probiotics in the prevention and treatment of antibiotic-associated diarrhea and Clostridium difficile colitis

Gastroenterol Clin North Am. 2012 Dec;41(4):763-79. doi: 10.1016/j.gtc.2012.08.002. Epub 2012 Sep 28.


Clostridium difficile colitis is the most common gastrointestinal infection, exceeding all other gastrointestinal infections combined. There has been a dramatic increase in Clostridium difficile infection (CDI) worldwide during the past decade. Antibiotic therapy is a trigger precipitating antibiotic-associated diarrhea (AAD), which may lead to CDI. The antibiotic alters the protective, diverse bacteria allowing pathogenic bacteria to cause disease. Probiotics have been effective in reducing AAD and preventing CDI.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Clostridioides difficile*
  • Diarrhea / chemically induced
  • Diarrhea / microbiology
  • Diarrhea / prevention & control
  • Diarrhea / therapy*
  • Enterocolitis, Pseudomembranous / complications
  • Enterocolitis, Pseudomembranous / diagnosis
  • Enterocolitis, Pseudomembranous / prevention & control
  • Enterocolitis, Pseudomembranous / therapy*
  • Humans
  • Probiotics / therapeutic use*
  • Recurrence
  • Severity of Illness Index


  • Anti-Bacterial Agents