Connective tissue disease-associated lung disease

Immunol Allergy Clin North Am. 2012 Nov;32(4):513-36. doi: 10.1016/j.iac.2012.09.002.


This article provides a broad overview of the complex intersection between the connective tissue diseases (CTDs) and their pulmonary manifestations. Indirect pulmonary complications - such as respiratory infection and medication-induced lung toxicity - are briefly discussed, and the importance of a comprehensive assessment of the patient with CTD with respiratory symptoms is emphasized. A concise review of the many pulmonary manifestations of each specific CTD is provided, and particular emphasis is placed on CTD-associated interstitial lung disease.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / diagnosis
  • Connective Tissue Diseases / complications*
  • Connective Tissue Diseases / diagnosis*
  • Humans
  • Lung Diseases / complications*
  • Lung Diseases / diagnosis*
  • Lung Diseases / etiology
  • Lung Diseases, Interstitial / complications
  • Lung Diseases, Interstitial / diagnosis
  • Lung Diseases, Interstitial / etiology
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / diagnosis
  • Polymyositis / complications
  • Polymyositis / diagnosis
  • Sjogren's Syndrome / complications
  • Sjogren's Syndrome / diagnosis