Endothelial function and cardiovascular risk in patients with idiopathic sudden sensorineural hearing loss

Atherosclerosis. 2012 Dec;225(2):511-6. doi: 10.1016/j.atherosclerosis.2012.10.024. Epub 2012 Oct 11.

Abstract

Objective: To evaluate cardiovascular risk factors and pre-clinical atherosclerosis in subjects affected by idiopathic sudden sensorineural hearing loss (ISSHL).

Methods: In this study, 29 ISSHL patients and 29 healthy controls were evaluated. All of the patients underwent a complete audiovestibular and clinical evaluation. Carotid intima-media thickness (C-IMT) and flow-mediated dilation (FMD) of the brachial artery were assessed as early markers of atherosclerosis.

Results: Our results showed that FMD was significantly lower in the ISSHL patients than in the controls (5.6 ± 1.6% vs. 7.7 ± 3.7%, p < 0.01). Moreover, the total cholesterol and low density lipoprotein cholesterol were significantly higher in the ISSHL patients than in the controls (p < 0.05). The two groups did not differ with regards to C-IMT and other cardiovascular risk factors. Vestibular involvement was shown to be associated with lower FMD values (4.1 ± 1.7% vs. 5.8 ± 1.5%, p < 0.05). No relationship was found between C-IMT and vestibular involvement. Finally, multiple logistic regression highlighted the finding that only FMD values seemed to predispose individuals to developing ISSHL (p = 0.03, OR: 1.4).

Conclusions: ISSHL seemed to be associated with vascular endothelial dysfunction and an increased cardiovascular risk, which supports the hypothesis of a vascular aetiology for this disease.

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Brachial Artery / diagnostic imaging
  • Brachial Artery / physiopathology*
  • Carotid Arteries / diagnostic imaging
  • Carotid Artery Diseases / blood
  • Carotid Artery Diseases / diagnosis
  • Carotid Artery Diseases / etiology*
  • Carotid Artery Diseases / physiopathology
  • Carotid Intima-Media Thickness
  • Case-Control Studies
  • Chi-Square Distribution
  • Cholesterol / blood
  • Cholesterol, LDL / blood
  • Early Diagnosis
  • Endothelium, Vascular / diagnostic imaging
  • Endothelium, Vascular / physiopathology*
  • Female
  • Hearing Loss, Sensorineural / complications*
  • Hearing Loss, Sensorineural / diagnosis
  • Hearing Loss, Sensorineural / physiopathology
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Predictive Value of Tests
  • Risk Assessment
  • Risk Factors
  • Vasodilation*

Substances

  • Biomarkers
  • Cholesterol, LDL
  • Cholesterol