Sepsis syndrome, bloodstream infections, and device-related infections

Med Clin North Am. 2012 Nov;96(6):1203-23. doi: 10.1016/j.mcna.2012.08.008.


The diagnosis of sepsis is challenging given the lack of appropriate diagnostic methods and the inaccuracy of diagnostic criteria. Early resuscitation, intravenous antibiotics, and source control are crucial in the management of septic patients. The treatment of catheter-related bloodstream infection (CRBSI) often comprises 1 to 2 weeks of intravenous antibiotics plus catheter removal. Infections related to surgical devices are more difficult to manage because they require longer duration of therapy and possibly multiple surgical procedures. This review represents an update on the diagnosis and management of sepsis, catheter-related blood stream infections and some clinically important device-related infections.

Publication types

  • Review

MeSH terms

  • Bacteremia / diagnosis*
  • Bacteremia / drug therapy*
  • Bacteremia / epidemiology
  • Catheter-Related Infections / diagnosis*
  • Catheter-Related Infections / drug therapy*
  • Catheter-Related Infections / epidemiology
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Infection Control / methods
  • Risk Factors
  • Sepsis / diagnosis*
  • Sepsis / drug therapy*
  • Sepsis / epidemiology