Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance

Cell Metab. 2012 Nov 7;16(5):658-64. doi: 10.1016/j.cmet.2012.09.015. Epub 2012 Oct 25.


Resveratrol has been reported to improve metabolic function in metabolically abnormal rodents and humans, but it has not been studied in nonobese people with normal glucose tolerance. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the metabolic effects of 12 weeks of resveratrol supplementation (75 mg/day) in nonobese, postmenopausal women with normal glucose tolerance. Although resveratrol supplementation increased plasma resveratrol concentration, it did not change body composition, resting metabolic rate, plasma lipids, or inflammatory markers. A two-stage hyperinsulinemic-euglycemic clamp procedure, in conjunction with stable isotopically labeled tracer infusions, demonstrated that resveratrol did not increase liver, skeletal muscle, or adipose tissue insulin sensitivity. Consistent with the absence of in vivo metabolic effects, resveratrol did not affect its putative molecular targets, including AMPK, SIRT1, NAMPT, and PPARGC1A, in either skeletal muscle or adipose tissue. These findings demonstrate that resveratrol supplementation does not have beneficial metabolic effects in nonobese, postmenopausal women with normal glucose tolerance.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects
  • Adipose Tissue / metabolism
  • Antioxidants / pharmacology*
  • Body Composition / drug effects
  • Dietary Supplements
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Gene Expression Regulation / drug effects
  • Glucose Clamp Technique
  • Glucose Tolerance Test
  • Humans
  • Insulin / metabolism
  • Liver / drug effects
  • Liver / metabolism
  • Middle Aged
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / metabolism
  • Placebo Effect
  • Resveratrol
  • Stilbenes / blood
  • Stilbenes / pharmacology*


  • Antioxidants
  • Insulin
  • Stilbenes
  • Resveratrol

Associated data

  • GEO/GSE41168