Intravoxel incoherent motion imaging of the kidney: alterations in diffusion and perfusion in patients with renal dysfunction

Magn Reson Imaging. 2013 Apr;31(3):414-7. doi: 10.1016/j.mri.2012.08.004. Epub 2012 Oct 25.


Purpose: To investigate the relationship between estimated glomerular filtration rate (eGFR) and parameters calculated using intravoxel incoherent motion (IVIM) imaging of the kidneys.

Materials and methods: We studied 365 patients, divided into 4 groups based on eGFR levels (mL/min/1.73m(2)): group 1, eGFR≥80(n=80); group 2, eGFR 60-80 (n=156); group 3, eGFR 30-60 (n=114); and group 4 ,eGFR<30 (n=15). IVIM imaging was used to acquire diffusion-weighted images at 12 b values. The diffusion coefficient of pure molecular diffusion (D), the diffusion coefficient of microcirculation or perfusion (D*), and perfusion fraction (f) were compared among the groups using group 1 as control.

Results: In the renal cortex, D* values were significantly lower in groups 2, 3, and 4 than in group 1. The D value of renal cortex was significantly low in only group 3. In the renal medulla, the D* and D values were significantly lower only in groups 2 and 3, respectively.

Conclusion: As renal dysfunction progresses, renal perfusion might be reduced earlier and affected more than molecular diffusion in the renal cortex. These changes are effectively detected by IVIM MR imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Algorithms*
  • Blood Flow Velocity
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Kidney Diseases / pathology*
  • Kidney Diseases / physiopathology*
  • Magnetic Resonance Angiography / methods*
  • Male
  • Middle Aged
  • Renal Circulation*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Young Adult