Abstract
An efficient method for synthesis of anthranilic acids by Pd-catalyzed ortho-C-H amidation of benzoic acids is disclosed. The amidation is proposed to proceed by carboxylate-assisted ortho-C-H palladation to form an arylpalladium(II) complex, followed by nitrene insertion to the Pd-C bond.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzoates / chemistry*
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Carbon / chemistry
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Catalysis
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Coordination Complexes / chemistry
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Hydrogen / chemistry
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Palladium / chemistry*
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ortho-Aminobenzoates / chemical synthesis
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ortho-Aminobenzoates / chemistry*
Substances
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Benzoates
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Coordination Complexes
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ortho-Aminobenzoates
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Palladium
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Carbon
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Hydrogen