ClusterMine360: A Database of Microbial PKS/NRPS Biosynthesis

Nucleic Acids Res. 2013 Jan;41(Database issue):D402-7. doi: 10.1093/nar/gks993. Epub 2012 Oct 26.

Abstract

ClusterMine360 (http://www.clustermine360.ca/) is a database of microbial polyketide and non-ribosomal peptide gene clusters. It takes advantage of crowd-sourcing by allowing members of the community to make contributions while automation is used to help achieve high data consistency and quality. The database currently has >200 gene clusters from >185 compound families. It also features a unique sequence repository containing >10 000 polyketide synthase/non-ribosomal peptide synthetase domains. The sequences are filterable and downloadable as individual or multiple sequence FASTA files. We are confident that this database will be a useful resource for members of the polyketide synthases/non-ribosomal peptide synthetases research community, enabling them to keep up with the growing number of sequenced gene clusters and rapidly mine these clusters for functional information.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Genetic*
  • Genes, Bacterial
  • Internet
  • Multigene Family
  • Peptide Biosynthesis, Nucleic Acid-Independent
  • Peptide Synthases / classification
  • Peptide Synthases / genetics*
  • Phylogeny
  • Polyketide Synthases / classification
  • Polyketide Synthases / genetics*
  • Polyketides / metabolism
  • Software

Substances

  • Polyketides
  • Polyketide Synthases
  • Peptide Synthases
  • non-ribosomal peptide synthase