A molecular assay of tumor radiosensitivity: a roadmap towards biology-based personalized radiation therapy

Per Med. 2012 Jul;9(5):547-557. doi: 10.2217/pme.12.55.


The last two decades have seen technological developments that have led to more accurate delivery of radiation therapy (RT), which has resulted in clinical gains in many solid tumors. However, a fundamental question and perhaps the next major hurdle is whether biological strategies can be developed to further enhance the effectiveness and efficiency of RT. This article addresses the development of a novel genomics-based molecular assay to predict tumor radiosensitivity, and proposes that this assay may prove pivotal in the development of biologically guided RT.