Abstract
The enantioselective allylic amination of unactivated terminal olefins represents a direct and attractive strategy for the synthesis of enantioenriched amines. We have developed the first use of a nitrogen-containing reagent and a chiral palladium catalyst to convert unfunctionalized olefins into enantioenriched allylic amines via an ene reaction/[2,3]-rearrangement.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkenes / chemistry*
-
Allyl Compounds / chemistry*
-
Amination
-
Amines / chemical synthesis*
-
Amines / chemistry
-
Catalysis
-
Molecular Structure
-
Organometallic Compounds / chemistry*
-
Palladium / chemistry*
-
Stereoisomerism
Substances
-
Alkenes
-
Allyl Compounds
-
Amines
-
Organometallic Compounds
-
Palladium