Discussion: 'Topiramate in pregnancy and risk of oral clefts,' by Margulis et al

Am J Obstet Gynecol. 2012 Nov;207(5):e1-2. doi: 10.1016/j.ajog.2012.09.001. Epub 2012 Sep 7.


In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed: Margulis AV, Mitchell AA, Gilboa SM, et al; National Birth Defects Prevention Study. Use of topiramate in pregnancy and risk of oral clefts. Am J Obstet Gynecol 2012;207:405.e1-7.

Publication types

  • Clinical Conference
  • Comment

MeSH terms

  • Anticonvulsants / adverse effects*
  • Cleft Lip / chemically induced*
  • Cleft Palate / chemically induced*
  • Female
  • Fructose / adverse effects
  • Fructose / analogs & derivatives*
  • Humans
  • Pregnancy
  • Prenatal Exposure Delayed Effects / epidemiology*
  • Topiramate


  • Anticonvulsants
  • Topiramate
  • Fructose