A conserved HLA-A*02:28 associated HLA haplotype, A*02:28-B*15:11-DRB1*09:01, restricted to Taiwanese

Int J Immunogenet. 2013 Aug;40(4):270-1. doi: 10.1111/iji.12005. Epub 2012 Oct 25.

Abstract

HLA-A*02:28, found in a Korean and a Japanese, was reported independently to the IMGT/HLA database in 2003 and 2005, respectively. We report here eight Taiwanese unrelated bone marrow hematopoietic stem cell donors carrying A*02:28 detected during our routine HLA typing exercise. The probable HLA-A, -B and -DRB1 haplotype in association with A*02:28 may be deduced from the eight marrow stem cell donor as A*02:28-B*15:11-DRB1*09:01. Our result suggests A*02:28-B*15:11-DRB1*09:01 is a conserved HLA haplotype restricted to Taiwanese.

MeSH terms

  • Alleles
  • Asian People / genetics*
  • Base Sequence
  • Bone Marrow Cells / cytology
  • Conserved Sequence
  • Gene Frequency / genetics
  • HLA-A2 Antigen / genetics*
  • HLA-A2 Antigen / immunology
  • HLA-DRB1 Chains / genetics*
  • Haplotypes / genetics
  • Haplotypes / immunology
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells / cytology*
  • Histocompatibility Testing
  • Humans
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • Taiwan

Substances

  • HLA-A*02 antigen
  • HLA-A2 Antigen
  • HLA-DRB1 Chains

Associated data

  • GENBANK/HE983615