Effects of a high protein diet on body weight and comorbidities associated with obesity

Br J Nutr. 2012 Aug:108 Suppl 2:S122-9. doi: 10.1017/S0007114512002322.


Red meat intake has been frequently associated with the development of coronary artery disease and type 2 diabetes but vegetable protein has been associated with protection from these diseases. Whether this is related to the protein per se or to the increased polyunsaturated fat or higher fibre levels associated with more vegetarian diets is not clear. High protein diets are associated with greater satiety and in some studies are associated with greater weight loss compared with high carbohydrate diets especially in an ad libitum design. These diets also lower plasma triglyceride and blood pressure and sometimes spare lean mass. There appear to be no harmful effects of high protein diets on bone density or renal function in weight loss studies.

MeSH terms

  • Animals
  • Blood Pressure
  • Body Composition / drug effects
  • Body Fluid Compartments / drug effects
  • Bone Density / drug effects
  • Coronary Artery Disease / complications
  • Coronary Artery Disease / prevention & control*
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / prevention & control*
  • Diet, Carbohydrate-Restricted
  • Diet, Reducing*
  • Diet, Vegetarian
  • Dietary Carbohydrates / pharmacology
  • Dietary Fats / pharmacology
  • Dietary Fiber / pharmacology
  • Dietary Proteins / pharmacology
  • Dietary Proteins / therapeutic use*
  • Humans
  • Kidney / drug effects
  • Meat
  • Obesity / complications
  • Obesity / diet therapy*
  • Satiation / drug effects
  • Triglycerides / blood
  • Vegetables / chemistry*
  • Weight Loss / drug effects*


  • Dietary Carbohydrates
  • Dietary Fats
  • Dietary Fiber
  • Dietary Proteins
  • Triglycerides