A new hydroxytyrosol metabolite identified in human plasma: hydroxytyrosol acetate sulphate

Food Chem. 2012 Sep 15;134(2):1132-6. doi: 10.1016/j.foodchem.2012.02.192. Epub 2012 Mar 7.

Abstract

We report progress in the study of olive oil phenolic metabolites in humans and identify a new hydroxytyrosol metabolite called hydroxytyrosol acetate sulphate, which was determined using tandem MS, after ingestion of 30 ml of olive oil with a high phenolic content (500 mg/kg oil), reaching a maximum concentration of 1.63 μM. In order to understand and explain the generation of this metabolite, two different pathways are proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Humans
  • Mass Spectrometry
  • Metabolic Networks and Pathways
  • Molecular Structure
  • Olive Oil
  • Phenols / analysis
  • Phenols / metabolism
  • Phenylethyl Alcohol / analogs & derivatives*
  • Phenylethyl Alcohol / blood
  • Phenylethyl Alcohol / chemistry
  • Phenylethyl Alcohol / metabolism
  • Plant Oils / analysis
  • Plant Oils / metabolism*

Substances

  • Olive Oil
  • Phenols
  • Plant Oils
  • 3,4-dihydroxyphenylethanol
  • Phenylethyl Alcohol