Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function

Chem Commun (Camb). 2012 Dec 14;48(96):11772-4. doi: 10.1039/c2cc36010a. Epub 2012 Oct 29.

Abstract

The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Ascomycota / chemistry
  • Ascomycota / enzymology*
  • Ascomycota / metabolism
  • Perylene / analogs & derivatives*
  • Perylene / chemistry
  • Perylene / metabolism
  • Polyketide Synthases / chemistry
  • Polyketide Synthases / metabolism*
  • Protein Structure, Tertiary
  • Pyrones / chemistry
  • Pyrones / metabolism*
  • Thiolester Hydrolases / chemistry
  • Thiolester Hydrolases / metabolism

Substances

  • Pyrones
  • Perylene
  • Polyketide Synthases
  • cercosporin
  • Thiolester Hydrolases