High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

Arq Bras Endocrinol Metabol. 2012 Oct;56(7):423-8. doi: 10.1590/s0004-27302012000700003.


Objectives: Vitamin D deficiency is common at all ages, and low levels of vitamin D have been associated with high incidence of type 1 diabetes. Similar results are not consistent for type 2 diabetes. The aim of the present study was to estimate vitamin D status in newly detected youth-onset diabetes in north India.

Subjects and methods: This was a prospective case control study at a tertiary care hospital in north India. Seventy two newly detected youth-onset diabetes subjects (age < 25 years), and 41 age- and gender-matched healthy controls were studied. In addition to basic information and management regarding their diabetes, metabolic parameters and serum 25(OH)D were measured in both the groups.

Results: Vitamin D deficiency was seen in 91.1% of the subjects with diabetes, and 58.5% of the healthy controls. Mean ±SD 25(OH)D was significantly low, 7.88 ± 1.20 ng/mL in subjects with diabetes against 16.64 ± 7.83 ng/mL in controls. Sixty percent of cases had severe Vitamin D deficiency compared with 8.3% in controls. Levels of vitamin D did not correlate with clinical parameters, such as gender, body mass index; or with biochemical parameters, such as serum calcium, phosphorus, alkaline phosphatase, fasting plasma glucose, and HbA1C.

Conclusion: Vitamin D deficiency is common in people with youth-onset diabetes.

MeSH terms

  • Adolescent
  • Body Mass Index
  • Case-Control Studies
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / diagnosis
  • Diabetes Mellitus, Type 1 / epidemiology*
  • Female
  • Humans
  • India / epidemiology
  • Male
  • Prevalence
  • Prospective Studies
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / epidemiology*