Nordic walking decreased circulating chemerin and leptin concentrations in middle-aged men with impaired glucose regulation

Ann Med. 2013 Mar;45(2):162-70. doi: 10.3109/07853890.2012.727020. Epub 2012 Oct 30.


Background: Dysfunction of adipose tissue is one of the major factors leading to insulin resistance. Altered adipokine concentration is an early sign of adipose tissue dysfunction. The aim of this study was to assess the impact of exercise intervention on adipokine profile, glycemic control, and risk factors of the metabolic syndrome (MeS) in men with impaired glucose regulation (IGR).

Methods: Overweight and obese men with IGR (n =144) aged 40-65 years were studied at baseline and at 12 weeks in a randomized controlled multicenter intervention study. BMI varied from 25.1 to 34.9. The subjects were randomized into one of three groups: 1) a control group (C; n =47), 2) a Nordic walking group (NW; n =48), or 3) a resistance training group (RT; n =49).

Results: Leptin concentrations decreased in the NW group compared to both other groups. Both types of exercise intervention significantly decreased serum chemerin concentrations compared to the C group. In the NW group also body fat percentage, fatty liver index (FLI), and total and LDL cholesterol concentrations decreased compared to the RT group.

Conclusions: Nordic walking intervention seems to decrease chemerin and leptin levels, and subjects in this intervention group achieved the most beneficial effects on components of MeS.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / metabolism*
  • Chemokines / blood*
  • Exercise / physiology*
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Leptin / blood*
  • Male
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / metabolism
  • Middle Aged
  • Obesity / blood*
  • Obesity / metabolism
  • Overweight / blood*
  • Overweight / metabolism
  • Risk Factors
  • Walking / physiology*


  • Blood Glucose
  • Chemokines
  • Intercellular Signaling Peptides and Proteins
  • Leptin
  • RARRES2 protein, human