Free and protein-bound angiotensin II(1-7)in the regulation of drinking behavior and hemodynamics in rats

Bull Exp Biol Med. 2012 Sep;153(5):623-6. doi: 10.1007/s10517-012-1782-9.

Abstract

We compared physiological activity of synthetic analogues of endogenous protein-peptide compounds, complexes of angiotensin II(1-7)with functionally different proteins (transport protein, serum albumin; and neurospecific Ca(2+)-binding protein, S100b). Physiological activity of angiotensin II(1-7)was shown to depend on the type of a carrier protein. Our results suggest that complexes of angiotensins with BSA and S100b are strong factors for the integration of central and peripheral functions at the homeostatic and behavioral level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin I / administration & dosage
  • Angiotensin I / metabolism
  • Angiotensin I / pharmacology*
  • Animals
  • Carrier Proteins / metabolism
  • Drinking Behavior / drug effects
  • Drinking Behavior / physiology*
  • Hemodynamics / drug effects
  • Hemodynamics / physiology*
  • Injections, Intraperitoneal
  • Male
  • Multiprotein Complexes / administration & dosage*
  • Multiprotein Complexes / metabolism
  • Multiprotein Complexes / pharmacology*
  • Nerve Growth Factors / metabolism
  • Peptide Fragments / administration & dosage
  • Peptide Fragments / metabolism
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Wistar
  • Renin-Angiotensin System / drug effects
  • Renin-Angiotensin System / physiology*
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins / metabolism
  • Serum Albumin / metabolism

Substances

  • Carrier Proteins
  • Multiprotein Complexes
  • Nerve Growth Factors
  • Peptide Fragments
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins
  • S100b protein, rat
  • Serum Albumin
  • Angiotensin I
  • angiotensin I (1-7)