DropletMicroarray: facile formation of arrays of microdroplets and hydrogel micropads for cell screening applications

Lab Chip. 2012 Dec 21;12(24):5218-24. doi: 10.1039/c2lc40921f.


We describe a one-step method for creating thousands of isolated pico- to microliter-sized droplets with defined geometry and volume. Arrays of droplets are instantly formed as liquid moves along a superhydrophilic-superhydrophobic patterned surface. Bioactive molecules, nonadherent cells, or microorganisms can be trapped in the fully isolated microdroplets for high-throughput screening, or in hydrogel micropads for screening in 3D microenvironments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Separation / instrumentation*
  • Cell Survival
  • Cellular Microenvironment
  • Doxorubicin / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Hydrogels / chemistry*
  • Microfluidic Analytical Techniques / methods*


  • Hydrogels
  • Doxorubicin