Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer

Biomarkers. 2013 Feb;18(1):88-94. doi: 10.3109/1354750X.2012.738250. Epub 2012 Nov 2.


Context: TK1 found to be elevated biomarker in many solid cancers.

Objectives: The study aimed to assess the prognostic significance of a serum TK1 in patients with metastatic NSCLC.

Methods: The study included 48 consecutive patients, newly diagnosed with metastatic NSCLC, and 10 healthy volunteers. Serum TK1 activity determined by ELISA method.

Results: Patients with a bTK1 level >156 Du L(-1) had significantly shorter survival. TK1 level showed a strong correlation with primary tumor SUV(max).

Discussion and conclusion: The magnitude of maximum fluorodeoxyglucose uptake in primary tumors and the serum TK1 level in patients with metastatic NSCLC were found to be independent prognostic predictors of overall survival.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers, Tumor / blood*
  • Carcinoma, Non-Small-Cell Lung / diagnostic imaging*
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Carcinoma, Non-Small-Cell Lung / mortality
  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Female
  • Fluorodeoxyglucose F18*
  • Humans
  • Kaplan-Meier Estimate
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Multimodal Imaging
  • Neoplasm Metastasis / physiopathology
  • Positron-Emission Tomography
  • Prognosis
  • Prospective Studies
  • Radiopharmaceuticals*
  • Thymidine Kinase / blood*
  • Tomography, X-Ray Computed


  • Biomarkers, Tumor
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Thymidine Kinase
  • thymidine kinase 1