Health-related quality of life in chronic myeloid leukemia

Leuk Res. 2013 Jan;37(1):9-13. doi: 10.1016/j.leukres.2012.09.013. Epub 2012 Oct 29.


The increased survival associated with treatments for CML emphasize the importance of understanding the HRQOL of newly diagnosed and previously treated CML patients with all phases of disease. Functional Assessment of Cancer Therapy-Leukemia results from a phase 3 and a phase 2 trial are reported for over 900 1st, 2nd, 3rd line CP, AP, and BP patients. Physical Well-being and Leukemia symptoms were worse for patients in later lines of therapy. Individuals with AP and BP CML had poorer HRQOL than individuals with CP CML. HRQOL of CML patients was predominantly consistent with the longitudinal clinical trajectory of the disease.

Trial registration: NCT00261846 NCT00574873.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Female
  • Health Status
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / physiopathology*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / psychology
  • Male
  • Middle Aged
  • Quality of Life*

Associated data