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, 7 (10), e48307

Chronic Medical Conditions and Risk of Sepsis


Chronic Medical Conditions and Risk of Sepsis

Henry E Wang et al. PLoS One.


Background: We sought to determine the associations between baseline chronic medical conditions and future risk of sepsis.

Methods: Longitudinal cohort study using the 30,239 community-dwelling participants of the REGARDS cohort. We determined associations between baseline chronic medical conditions and incident sepsis episodes, defined as hospitalization for an infection with the presence of infection plus two or more systemic inflammatory response syndrome criteria.

Results: Over the mean observation time of 4.6 years (February 5, 2003 through October 14, 2011), there were 975 incident cases of sepsis. Incident sepsis episodes were associated with older age (p<0.001), white race (HR 1.39; 95% CI: 1.22-1.59), lower education (p<0.001) and income (p<0.001), tobacco use (p<0.001), and alcohol use (p = 0.02). Incident sepsis episodes were associated with baseline chronic lung disease (adjusted HR 2.43; 95% CI: 2.05-2.86), peripheral artery disease (2.16; 1.58-2.95), chronic kidney disease (1.99; 1.73-2.29), myocardial infarction 1.79 (1.49-2.15), diabetes 1.78 (1.53-2.07), stroke 1.67 (1.34-2.07), deep vein thrombosis 1.63 (1.29-2.06), coronary artery disease 1.61 (1.38-1.87), hypertension 1.49 (1.29-1.74), atrial fibrillation 1.48 (1.21-1.81) and dyslipidemia 1.16 (1.01-1.34). Sepsis risk increased with the number of chronic medical conditions (p<0.001).

Conclusions: Individuals with chronic medical conditions are at increased risk of future sepsis events.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.


Figure 1
Figure 1. Adjusted risk of incident sepsis versus number of chronic medical conditions.
Total of 975 incident sepsis events among 30,239 participants in the REGARDS cohort. Chronic medical conditions included hypertension, diabetes, dyslipidemia, coronary artery disease, atrial fibrillation, myocardial infarction, stroke, deep vein thrombosis, peripheral artery disease, chronic kidney disease and chronic lung disease. Hazard ratios adjusted for age, sex, race, education, income, geographic region, smoking status and alcohol use. P-value for test of trend <0.001.

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