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Review
. 2012 Oct;58(10):743-9.

[Vitamin C and Its Physiological Role With Respect to the Components of the Immune System]

[Article in Czech]
Affiliations
  • PMID: 23121060
Review

[Vitamin C and Its Physiological Role With Respect to the Components of the Immune System]

[Article in Czech]
D Holmannová et al. Vnitr Lek. .

Abstract

Vitamin C is a water soluble micronutrient commonly found in our diet which orchestrates the function of both innate and adaptive immune system, influencing both cellular and humoral immune responses. Vitamin C inhibits excessive activation of the immune system to prevent tissue damage, but also supports antibacterial activity, stimulates NK cells and differentiation of Th0 subset into Th1 characterized by interferon γ production. In addition, vitamin C interferes with the synthesis of proinflammatory cytokines, or with the expression of adhesive molecules. Moreover, vitamin C as an antioxidat protects the immune cells against intracellular ROS (reactive oxygen species) formed in the inflammatory response. Vitamin C as an enzymatic cofactor is extremely important in maintaining tissue integrity, and plays a crucial role in formation of skin, epithelial and endothelial barriers.

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