Should the ketogenic diet be considered for enhancing fertility?

Maturitas. 2013 Jan;74(1):10-3. doi: 10.1016/j.maturitas.2012.10.003. Epub 2012 Oct 31.


The ketogenic diet was first developed in the 1920s as a treatment for epilepsy in an attempt to create a prolonged physiologic starvation state. Since that time, the diet has been found to have other therapeutic effects, most of which are neurologic. Other diets, mostly based on the principals of caloric restriction, have been shown to improve fertility in certain populations. We explore the data, both clinical and laboratory, for potential fertility enhancing benefits of the ketogenic diet, beyond just caloric restriction or weight loss.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Caloric Restriction
  • Diet, Ketogenic*
  • Epilepsy / diet therapy
  • Female
  • Glycolysis
  • Humans
  • Infertility, Female / diet therapy*
  • Ketone Bodies / metabolism
  • Weight Loss


  • Ketone Bodies